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Fair value of financial instruments - Rollforward of Level 3 liabilities (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Rollforward of Level 3 liabilities          
Change in fair value of contingent consideration $ 4,720 $ (16,343) $ 18,708 $ (1,914)  
ARIAD Pharmaceuticals          
Rollforward of Level 3 liabilities          
Contingent consideration earned during the period but not yet paid (6,700)   (6,300)   $ (6,600)
Fair Value | Level 3          
Rollforward of Level 3 liabilities          
Balance at beginning of period     287,000    
Contingent consideration earned during the period but not yet paid     (13,023)    
Payments made during the period     (6,685)    
Change in fair value of contingent consideration     18,708    
Balance at end of period $ 286,000   $ 286,000   $ 287,000