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Summary of significant accounting policies - Narrative 2 (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Jan. 01, 2018
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Revenue recognition            
Percentage of Medicare Part D insurance coverage gap mandate to be funded by manufacturers       50.00%    
Accrued clinical and research development costs   $ 115,000   $ 115,000   $ 110,000
Recent Accounting Pronouncements            
Net income   $ 29,176 $ 36,054 40,430 $ (163,513)  
ASU 2016-01 | Calithera            
Recent Accounting Pronouncements            
Net income $ 2,800          
Product revenues, net            
Revenue recognition            
Accrued allowances       $ 39,800   $ 34,700
ICLUSIG            
Revenue recognition            
Amortization period       12 years 6 months