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Represents the earning recognized and the payment received for the achievement of a predefined milestone under the license agreement.

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No definition available.

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Represents the number of deliverables under the license agreement.

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Represents the amount of the upfront payment made under the license agreement.

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Represents the upfront and immediate milestone payment received under the license agreement.

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- Definition

Represents the percentage of associated royalty payments from the initiation of a Phase IIb trial provided the entity elects not to co-develop any compounds and/or indications.

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No definition available.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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License agreements - Lilly (Details) $ in Thousands	1 Months Ended			3 Months Ended		6 Months Ended		12 Months Ended				103 Months Ended
License agreements - Lilly (Details) $ in Thousands	Mar. 31, 2016 USD ($)	Jul. 31, 2010	Dec. 31, 2009 USD ($) item	Jun. 30, 2018 USD ($)	Jun. 30, 2017 USD ($)	Jun. 30, 2018 USD ($)	Jun. 30, 2017 USD ($)	Dec. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)	Dec. 31, 2012 USD ($)	Dec. 31, 2010 USD ($)	Jun. 30, 2018 USD ($)
License agreements
Research and Development Expense				$ 298,089	$ 201,786	$ 601,192	$ 609,706
Revenues				521,500		903,800
Milestone revenues
License agreements
Revenues				100,000		100,000
Product royalty revenues
License agreements
Revenues				56,000		103,700
Eli Lilly
License agreements
Upfront payment received under license agreement			$ 90,000
Research and Development Expense				14,200	8,700	26,700	18,100
Number of deliverables under license agreement \| item			2
Product royalties in accounts receivable				$ 8,900		$ 8,900		$ 4,600				$ 8,900
Eli Lilly \| Maximum
License agreements
Associated future royalty payments from the initiation of a Phase IIb trial, if elected to not co-develop, percentage						20.00%
Eli Lilly \| Phase IIB
License agreements
Funding of future development costs (as a percent)		30.00%		30.00%		30.00%
Eli Lilly \| Pre-specified Events \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement			$ 665,000
Eli Lilly \| Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone								30,000				129,000
Eli Lilly \| Development Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement			150,000
Eli Lilly \| Development Milestones \| Phase III
License agreements
Amount recognized and received for the achievement of a predefined milestone										$ 50,000
Eli Lilly \| Development Milestones \| Phase IIA
License agreements
Amount recognized and received for the achievement of a predefined milestone											$ 30,000
Eli Lilly \| Development Milestones \| Phase IIB
License agreements
Amount recognized and received for the achievement of a predefined milestone											$ 19,000
Eli Lilly \| Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone				$ 100,000								$ 235,000
Eli Lilly \| Regulatory Milestones \| JAPAN
License agreements
Amount recognized and received for the achievement of a predefined milestone								15,000
Eli Lilly \| Regulatory Milestones \| U.S.
License agreements
Amount recognized and received for the achievement of a predefined milestone									$ 35,000
Eli Lilly \| Regulatory Milestones \| Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone								$ 65,000	$ 20,000
Eli Lilly \| Regulatory Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement			365,000
Eli Lilly \| Commercialization Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement			$ 150,000
Eli Lilly \| GVHD
License agreements
Upfront payment under license agreement	$ 35,000
Additional milestone payments under the license agreement	$ 40,000
Eli Lilly \| Milestone revenues
License agreements
Revenues				100,000	0	$ 100,000	65,000
Eli Lilly \| Product royalty revenues
License agreements
Revenues				$ 8,900	$ 900	$ 15,300	$ 1,300