CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Total revenues	$ 521,516	$ 326,444	$ 903,798	$ 710,526
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	24,856	20,260	42,962	35,084
Research and development	298,089	201,786	601,192	609,706
Selling, general and administrative	108,029	90,066	229,527	177,295
Change in fair value of acquisition-related contingent consideration	7,303	7,073	13,988	14,429
Total costs and expenses	438,277	319,185	887,669	836,514
Income (loss) from operations	83,239	7,259	16,129	(125,988)
Other income (expense), net	5,808	4,066	10,270	5,213
Interest expense	(398)	(384)	(783)	(6,323)
Unrealized loss on long term investments	(34,641)	(19,574)	(11,962)	(25,388)
Expense related to senior note conversions		(751)		(54,881)
Income (loss) before provision (benefit) for income taxes	54,008	(9,384)	13,654	(207,367)
Provision (benefit) for income taxes	1,614	3,100	2,400	(7,800)
Net income (loss)	$ 52,394	$ (12,484)	$ 11,254	$ (199,567)
Net income (loss) per share:
Basic	$ 0.25	$ (0.06)	$ 0.05	$ (1.00)
Diluted	$ 0.24	$ (0.06)	$ 0.05	$ (1.00)
Shares used in computing net income (loss) per share:
Basic	212,210	205,141	211,945	200,200
Diluted	215,103	205,141	215,294	200,200
Product revenues, net
Revenues:
Total revenues	$ 365,524	$ 291,667	$ 700,029	$ 556,474
Product royalty revenues
Revenues:
Total revenues	55,953	34,769	103,669	63,990
Milestone revenues
Revenues:
Total revenues	100,000		100,000	90,000
Other revenues
Revenues:
Total revenues	$ 39	$ 8	$ 100	$ 62