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License agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended
Dec. 31, 2017
Mar. 31, 2018
Mar. 31, 2017
License agreements      
Research and development   $ 303,103 $ 407,920
MacroGenics      
License agreements      
Upfront payment under license agreement $ 150,000    
Research and development   6,500  
MacroGenics | Accrued and other liabilities      
License agreements      
Accrued and other liabilities $ 1,100 $ 7,500  
Minimum | MacroGenics      
License agreements      
Royalty payments on future global net sales (as a percent) 15.00%    
Maximum | MacroGenics      
License agreements      
Royalty payments on future global net sales (as a percent) 24.00%    
Development and Regulatory Milestones | Maximum | MacroGenics      
License agreements      
Additional milestone payments under the license agreement $ 420,000    
Commercialization Milestones | Minimum | MacroGenics      
License agreements      
Additional milestone payments under the license agreement $ 330,000