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Summary of significant accounting policies - Narrative 2 (Details) - USD ($)
$ in Thousands
3 Months Ended
Jan. 01, 2018
Mar. 31, 2018
Mar. 31, 2017
Revenue recognition      
Percentage of Medicare Part D insurance coverage gap mandate to be funded by manufacturers   50.00%  
Stock-Based Compensation      
Stock-based compensation expense   $ 36,200 $ 30,600
Recent Accounting Pronouncements      
Net income   $ (41,140) $ (187,083)
ASU 2016-01 | Calithera      
Recent Accounting Pronouncements      
Net income $ 2,800    
ICLUSIG      
Revenue recognition      
Amortization period   12 years 6 months