XML 69 R52.htm IDEA: XBRL DOCUMENT v3.8.0.1
License agreements - Lilly (Details)
$ in Thousands
1 Months Ended 12 Months Ended 97 Months Ended
Jan. 31, 2017
Mar. 31, 2016
USD ($)
Jul. 31, 2010
Dec. 31, 2009
USD ($)
item
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2012
USD ($)
Dec. 31, 2010
USD ($)
Dec. 31, 2017
USD ($)
License agreements                    
Research and Development Expense         $ 1,326,361 $ 581,861 $ 479,514      
Milestone and contract revenues         175,000 112,512 77,857      
Product royalty revenues         $ 160,791 110,711 74,821      
Eli Lilly                    
License agreements                    
Upfront payment received under license agreement       $ 90,000            
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop (as a percentage) 30.00%       30.00%          
Research and Development Expense         $ 40,800 27,300 36,000      
Number of deliverables under license agreement | item       2            
Milestone and contract revenues         110,000 67,500 $ 12,900      
Product royalties in accounts receivable         4,600         $ 4,600
Eli Lilly | Non-U.S.                    
License agreements                    
Product royalty revenues         9,100          
Eli Lilly | Phase IIB                    
License agreements                    
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop (as a percentage)     30.00% 30.00%            
Eli Lilly | Pre-specified Events | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement       $ 665,000            
Eli Lilly | Development Milestones                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone         30,000         129,000
Eli Lilly | Development Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement       150,000            
Eli Lilly | Development Milestones | Phase III                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone               $ 50,000    
Eli Lilly | Development Milestones | Phase IIA                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone                 $ 30,000  
Eli Lilly | Development Milestones | Phase IIB                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone                 $ 19,000  
Eli Lilly | Regulatory Milestones                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone           35,000       $ 135,000
Eli Lilly | Regulatory Milestones | JAPAN                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone         15,000          
Eli Lilly | Regulatory Milestones | Europe                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone         $ 65,000 20,000        
Eli Lilly | Regulatory Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement       365,000            
Eli Lilly | Commercialization Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement       $ 150,000            
Royalty payments on future global net sales (as a percent)         20.00%          
Eli Lilly | GVHD                    
License agreements                    
Upfront payment received under license agreement   $ 35,000                
Additional milestone payment received under license agreement   $ 40,000                
Research and development expenses reimbursed           $ 35,000