CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Product revenues, net	$ 322,029	$ 236,623	$ 878,503	$ 632,006
Product royalty revenues	44,487	29,626	108,477	77,486
Contract revenues	15,000	3,214	105,000	69,643
Other revenues	18	6	80	86
Total revenues	381,534	269,469	1,092,060	779,221
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	22,036	20,205	57,120	38,577
Research and development	269,612	143,184	879,423	420,276
Selling, general and administrative	91,271	75,776	268,577	207,166
Change in fair value of acquisition-related contingent consideration	(16,343)	8,012	(1,914)	10,283
Total costs and expenses	366,576	247,177	1,203,206	676,302
Income (loss) from operations	14,958	22,292	(111,146)	102,919
Interest and other income, net	5,555	1,188	10,884	3,818
Interest expense	(204)	(9,479)	(6,527)	(29,275)
Unrealized gain (loss) on long term investments	23,045	24,301	(2,343)	20,497
Expense related to senior note conversions			(54,881)
Income (loss) before provision (benefit) for income taxes	43,354	38,302	(164,013)	97,959
Provision (benefit) for income taxes	7,300	1,425	(500)	2,610
Net income (loss)	$ 36,054	$ 36,877	$ (163,513)	$ 95,349
Net income (loss) per share:
Basic	$ 0.17	$ 0.20	$ (0.81)	$ 0.51
Diluted	$ 0.17	$ 0.19	$ (0.81)	$ 0.49
Shares used in computing net income (loss) per share:
Basic	206,796	188,029	202,399	187,632
Diluted	212,610	194,265	202,399	193,754