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License agreements - Lilly (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended 91 Months Ended
Jan. 31, 2017
Mar. 31, 2016
USD ($)
Jul. 31, 2010
Dec. 31, 2009
USD ($)
item
Jun. 30, 2017
USD ($)
Jun. 30, 2016
USD ($)
Jun. 30, 2017
USD ($)
Jun. 30, 2016
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2012
USD ($)
Dec. 31, 2010
USD ($)
Jun. 30, 2017
USD ($)
License agreements                        
Research and Development Expense         $ 201,839 $ 120,269 $ 609,811 $ 277,092        
Contract revenues           8,214 $ 90,000 66,429        
Lilly                        
License agreements                        
Upfront payment received under license agreement       $ 90,000                
Funding of future development costs (as a percent)             30.00%          
Research and Development Expense         8,700 5,300 $ 18,100 10,400        
Number of deliverables under license agreement | item       2                
Contract revenues         0 $ 3,200 65,000 61,400        
Net sales         900   1,300          
Product royalties in accounts receivable         $ 1,000   $ 1,000         $ 1,000
Lilly | Maximum                        
License agreements                        
Associated future royalty payments from the initiation of a Phase IIb trial, if elected to not co-develop, percentage             20.00%          
Lilly | Phase Two A                        
License agreements                        
Funding of future development costs (as a percent) 30.00%                      
Lilly | Phase Two B                        
License agreements                        
Funding of future development costs (as a percent)     30.00%       30.00%          
Lilly | Pre-specified Events | Maximum                        
License agreements                        
Upfront and immediate milestone payment to be received under license agreement       $ 665,000                
Lilly | Development Milestones                        
License agreements                        
Amount recognized and received for the achievement of a predefined milestone                       99,000
Lilly | Development Milestones | Maximum                        
License agreements                        
Upfront and immediate milestone payment to be received under license agreement       150,000                
Lilly | Development Milestones | Phase Three                        
License agreements                        
Amount recognized and received for the achievement of a predefined milestone                   $ 50,000    
Lilly | Development Milestones | Phase Two A                        
License agreements                        
Amount recognized and received for the achievement of a predefined milestone                     $ 30,000  
Lilly | Development Milestones | Phase Two B                        
License agreements                        
Amount recognized and received for the achievement of a predefined milestone                     $ 19,000  
Lilly | Regulatory Milestones                        
License agreements                        
Amount recognized and received for the achievement of a predefined milestone                       $ 120,000
Lilly | Regulatory Milestones | U.S.                        
License agreements                        
Amount recognized and received for the achievement of a predefined milestone                 $ 35,000      
Lilly | Regulatory Milestones | Europe                        
License agreements                        
Amount recognized and received for the achievement of a predefined milestone             $ 65,000   $ 20,000      
Lilly | Regulatory Milestones | Maximum                        
License agreements                        
Upfront and immediate milestone payment to be received under license agreement       365,000                
Lilly | Commercialization Milestones | Maximum                        
License agreements                        
Upfront and immediate milestone payment to be received under license agreement       $ 150,000                
Lilly | GVHD                        
License agreements                        
Research and Development Expense               $ 35,000        
Upfront payment under license agreement   $ 35,000                    
Additional milestone payments under the license agreement   $ 40,000