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Concentration of Credit Risk (Details)
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Dec. 31, 2016
Contract Revenues | Customer Concentration Risk | Collaboration Partner A          
Concentration of risk          
Percentage of concentration risk   61.00% 28.00% 8.00%  
Contract Revenues | Customer Concentration Risk | Collaboration Partner B          
Concentration of risk          
Percentage of concentration risk   39.00% 72.00% 92.00%  
Sales Revenue | Customer Concentration Risk | Customer A          
Concentration of risk          
Percentage of concentration risk 23.00% 26.00% 25.00% 27.00%  
Sales Revenue | Customer Concentration Risk | Customer B          
Concentration of risk          
Percentage of concentration risk 16.00% 16.00% 16.00% 17.00%  
Sales Revenue | Customer Concentration Risk | Customer C          
Concentration of risk          
Percentage of concentration risk 13.00% 13.00% 13.00% 13.00%  
Sales Revenue | Customer Concentration Risk | Customer D          
Concentration of risk          
Percentage of concentration risk 9.00% 9.00% 8.00% 9.00%  
Accounts Receivable | Credit Concentration Risk | Collaboration Partner A and B          
Concentration of risk          
Percentage of concentration risk     21.00%   23.00%
Accounts Receivable | Credit Concentration Risk | Customer A B C and D          
Concentration of risk          
Percentage of concentration risk     46.00%   41.00%