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Fair value of financial instruments - Rollforward of Level 3 liabilities (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Rollforward of Level 3 liabilities        
Change in fair value of contingent consideration $ 7,073 $ 2,271 $ 14,429 $ 2,271
ARIAD Pharmaceuticals        
Rollforward of Level 3 liabilities        
Contingent consideration earned during the period but not yet paid (5,100)      
Royalties paid 4,400      
Fair Value | Level 3        
Rollforward of Level 3 liabilities        
Balance at beginning of period     301,000  
Contingent consideration earned during the period but not yet paid     (5,073)  
Payments made during the period     (4,356)  
Change in fair value of contingent consideration     14,429  
Balance at end of period $ 306,000   $ 306,000