CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Product revenues, net	$ 264,807	$ 183,267
Product royalty revenues	29,221	21,903
Contract revenues	90,000	58,214
Other revenues	54	80
Total revenues	384,082	263,464
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	14,824	6,005
Research and development	407,972	156,824
Selling, general and administrative	87,234	64,596
Change in fair value of acquisition-related contingent consideration	7,356
Total costs and expenses	517,386	227,425
Income (loss) from operations	(133,304)	36,039
Interest and other income, net	1,204	1,492
Interest expense	(5,939)	(10,134)
Unrealized loss on long term investments	(5,814)	(2,950)
Expense related to senior note conversions	(54,130)
Income (loss) before provision (benefit) for income taxes	(197,983)	24,447
Provision (benefit) for income taxes	(10,900)	400
Net income (loss)	$ (187,083)	$ 24,047
Net income (loss) per share:
Basic	$ (0.96)	$ 0.13
Diluted	$ (0.96)	$ 0.12
Shares used in computing net income (loss) per share:
Basic	195,260	187,184
Diluted	195,260	192,625