The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 730
-SubTopic 10
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 985
-SubTopic 20
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756

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Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

License agreements - Hengrui (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015	Dec. 31, 2015	Sep. 01, 2015
License agreements
Research and development expense	$ 143,184	$ 132,073	$ 420,276	$ 362,882
Hengrui
License agreements
Upfront payment made under license agreement					$ 25,000
Potential milestone payments to be made						$ 770,000
Research and development expense	$ 3,300		$ 5,500
Hengrui \| Regulatory Milestones
License agreements
Potential milestone payments to be made						90,000
Hengrui \| Commercialization Milestones
License agreements
Potential milestone payments to be made						530,000
Hengrui \| Clinical Superiority Milestones
License agreements
Potential milestone payments to be made						$ 150,000