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License agreements (Details) $ in Thousands	1 Months Ended								3 Months Ended			6 Months Ended	9 Months Ended		12 Months Ended						79 Months Ended	80 Months Ended
License agreements (Details) $ in Thousands	Apr. 30, 2016 USD ($)	Mar. 31, 2016 USD ($)	Jan. 31, 2016 USD ($)	Sep. 30, 2014 USD ($)	Jul. 31, 2010	Jan. 31, 2010 USD ($)	Dec. 31, 2009 USD ($) item	Nov. 30, 2009 USD ($) item	Sep. 30, 2016 USD ($)	Jun. 30, 2016 USD ($)	Sep. 30, 2015 USD ($)	Jun. 30, 2016 USD ($)	Sep. 30, 2016 USD ($)	Sep. 30, 2015 USD ($)	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)	Dec. 31, 2012 USD ($)	Dec. 31, 2011 USD ($)	Dec. 31, 2010 USD ($)	Jun. 30, 2016 USD ($)	Jun. 30, 2016 USD ($)
License agreements
Research and Development Expense									$ 143,184		$ 132,073		$ 420,276	$ 362,882
Contract revenues									3,214		8,214		69,643	39,643
Product royalty revenues									29,626		18,138		77,486	51,175
Novartis
License agreements
Upfront and immediate milestone payment to be received under license agreement								$ 210,000
Product royalties in accounts receivable									29,800				29,800		$ 23,800
Number of deliverables under license agreement \| item								2
Upfront payment received under license agreement								$ 150,000
Immediate milestone payment received under license agreement						$ 60,000
Reimbursable costs recorded as deferred revenue							$ 10,900
Reimbursable costs included in accounts receivable									100				100		300
Research and development expenses reimbursed									300		300		700	1,300
Contract revenues									0		5,000		5,000	30,000
Additional milestone payment received under license agreement	$ 75,000
Novartis \| U.S.
License agreements
Royalties payable on net sales									10,900		7,400		25,100	15,500
Novartis \| Pre-specified Events \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement								1,200,000
Novartis \| Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone													5,000									$ 102,000
Novartis \| Development Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement								174,000
Novartis \| Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																						175,000
Novartis \| Regulatory Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement								495,000
Novartis \| Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																						$ 20,000
Novartis \| Commercialization Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement								$ 500,000
Novartis \| JAKAFI \| Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone															5,000	$ 7,000	$ 25,000		$ 15,000	$ 50,000
Novartis \| JAKAFI \| Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																			$ 10,000
Novartis \| JAKAFI \| Regulatory Milestones \| Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone															25,000	60,000		$ 40,000
Novartis \| JAKAFI \| Regulatory Milestones \| JAPAN
License agreements
Amount recognized and received for the achievement of a predefined milestone																$ 25,000
Novartis \| JAKAVI
License agreements
Net sales															300,000
Product royalty revenues									29,600		18,100		77,500	51,200
Novartis \| JAKAVI \| Regulatory Milestones \| Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone				$ 60,000
Novartis \| JAKAVI \| Regulatory Milestones \| JAPAN
License agreements
Amount recognized and received for the achievement of a predefined milestone															15,000
Novartis \| JAKAVI \| Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone															$ 20,000
Novartis \| Capmatinib \| Minimum
License agreements
Range of royalty payments on future global net sales (as a percent)								12.00%
Novartis \| Capmatinib \| Maximum
License agreements
Range of royalty payments on future global net sales (as a percent)								14.00%
Lilly
License agreements
Number of deliverables under license agreement \| item							2
Upfront payment received under license agreement							$ 90,000
Research and Development Expense									10,600		6,400		21,000	28,300
Contract revenues									$ 3,200		$ 3,200		$ 64,600	$ 9,600
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop, percentage					30.00%		30.00%		30.00%		30.00%		30.00%	30.00%
Lilly \| Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone			$ 20,000
Lilly \| U.S.
License agreements
Amount recognized and received for the achievement of a predefined milestone			$ 35,000
Lilly \| Maximum
License agreements
Range of royalty payments on future global net sales (as a percent)													20.00%
Associated future royalty payments from the initiation of a Phase IIb trial, if elected to not co-develop, percentage													20.00%
Lilly \| Pre-specified Events \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement							$ 665,000
Lilly \| Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																					$ 99,000
Lilly \| Development Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement							150,000
Lilly \| Development Milestones \| Phase Three
License agreements
Amount recognized and received for the achievement of a predefined milestone																		$ 50,000
Lilly \| Development Milestones \| Phase Two A
License agreements
Amount recognized and received for the achievement of a predefined milestone																				30,000
Lilly \| Development Milestones \| Phase Two B
License agreements
Amount recognized and received for the achievement of a predefined milestone																				$ 19,000
Lilly \| Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																					$ 55,000
Lilly \| Regulatory Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement							365,000
Lilly \| Commercialization Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement							$ 150,000
Lilly \| GVHD
License agreements
Upfront payment received under license agreement		$ 35,000
Research and Development Expense										$ 35,000		$ 35,000
Additional milestone payment received under license agreement		$ 40,000