Concentration of credit risk (Details)	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015	Dec. 31, 2015
Contract Revenues | Customer Concentration Risk | Collaboration Partner A
Concentration of risk
Percentage of concentration risk		61.00%	7.00%	76.00%
Contract Revenues | Customer Concentration Risk | Collaboration Partner B
Concentration of risk
Percentage of concentration risk	100.00%	39.00%	93.00%	24.00%
Sales Revenue | Customer Concentration Risk | Customer A
Concentration of risk
Percentage of concentration risk	25.00%	29.00%	26.00%	28.00%
Sales Revenue | Customer Concentration Risk | Customer B
Concentration of risk
Percentage of concentration risk	19.00%	18.00%	18.00%	19.00%
Sales Revenue | Customer Concentration Risk | Customer C
Concentration of risk
Percentage of concentration risk	13.00%	13.00%	13.00%	13.00%
Sales Revenue | Customer Concentration Risk | Customer D
Concentration of risk
Percentage of concentration risk	8.00%	9.00%	8.00%	9.00%
Accounts Receivable | Credit Concentration Risk | Collaboration Partner A and B
Concentration of risk
Percentage of concentration risk			23.00%		39.00%
Accounts Receivable | Credit Concentration Risk | Customer A B C and D
Concentration of risk
Percentage of concentration risk			40.00%		40.00%