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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Revenues:        
Product revenues, net $ 236,623 $ 161,259 $ 632,006 $ 418,994
Product royalty revenues 29,626 18,138 77,486 51,175
Contract revenues 3,214 8,214 69,643 39,643
Other revenues 6   86 58
Total revenues 269,469 187,611 779,221 509,870
Costs and expenses:        
Cost of product revenues (including definite-lived intangible amortization) 20,205 8,040 38,577 17,268
Research and development 143,184 132,073 420,276 362,882
Selling, general and administrative 75,776 47,599 207,166 144,147
Change in fair value of acquisition-related contingent consideration 8,012   10,283  
Total costs and expenses 247,177 187,712 676,302 524,297
Income (loss) from operations 22,292 (101) 102,919 (14,427)
Interest and other income, net 1,188 3,026 3,818 5,800
Interest expense (9,479) (11,209) (29,275) (35,390)
Unrealized gain (loss) on long term investment 24,301 (31,289) 20,497 (4,115)
Income (loss) before provision for income taxes 38,302 (39,573) 97,959 (48,132)
Provision for income taxes 1,425 9 2,610 513
Net income (loss) $ 36,877 $ (39,582) $ 95,349 $ (48,645)
Net income (loss) per share:        
Basic $ 0.20 $ (0.22) $ 0.51 $ (0.27)
Diluted $ 0.19 $ (0.22) $ 0.49 $ (0.27)
Shares used in computing net income (loss) per share:        
Basic 188,029 181,387 187,632 177,378
Diluted 194,265 181,387 193,754 177,378