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Summary of significant accounting policies - Narrative 2 (Details)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
USD ($)
Mar. 31, 2016
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2016
USD ($)
item
category
Sep. 30, 2015
USD ($)
Revenue Recognition          
Percentage of Medicare Part D insurance coverage gap mandate to be funded by manufacturers       50.00%  
Categories of milestone events, number | category       3  
Number of stages of life-cycle drugs | item       3  
Stock-Based Compensation          
Stock-based compensation expense $ 26,500   $ 17,600 $ 68,600 $ 52,800
Recent Accounting Pronouncements          
Excess tax benefits $ 1,425   $ 9 2,610 $ 513
Impact of Adoption of ASU No. 2016-09          
Recent Accounting Pronouncements          
Excess tax benefit from stock based compensation   $ 325,600      
Excess tax benefits       $ 900  
ICLUSIG          
Revenue Recognition          
Amortization period       12 years 6 months