CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015	[1]
Current assets:
Cash and cash equivalents	$ 580,099	$ 521,439
Marketable securities-available-for-sale	136,486	186,344
Restricted cash and investments	17	516
Accounts receivable	131,523	114,450
Inventory	4,078	1,783
Prepaid expenses and other current assets	34,457	17,843
Total current assets	886,660	842,375
Restricted cash and investments	932	13,977
Long term investment	55,745	35,248
Inventory	14,829	17,555
Property and equipment, net	151,942	86,006
Other intangible assets, net	263,821
In-process research and development	12,000
Goodwill	155,702
Other assets, net	2,564	12,279
Total assets	1,544,195	1,007,440
Current liabilities:
Accounts payable	57,524	30,085
Accrued compensation	47,414	38,117
Interest payable	2,285	762
Accrued and other current liabilities	112,600	86,531
Deferred revenue-collaborative agreements	2,868	12,512
Acquisition-related contingent consideration	17,854
Total current liabilities	240,545	168,007
Convertible senior notes	643,434	619,893
Acquisition-related contingent consideration	280,146
Other liabilities	10,084	48,385
Total liabilities	1,174,209	836,285
Stockholders' equity:
Preferred stock, $0.001 par value; 5,000,000 shares authorized; none issued or outstanding as of September 30, 2016 and December 31, 2015
Common stock, $0.001 par value; 400,000,000 shares authorized; 188,258,973 and 186,650,249 shares issued and outstanding as of September 30, 2016 and December 31, 2015, respectively	188	187
Additional paid-in capital	2,053,046	1,950,764
Accumulated other comprehensive income (loss)	390	(809)
Accumulated deficit	(1,683,638)	(1,778,987)
Total stockholders' equity	369,986	171,155
Total liabilities and stockholders' equity	$ 1,544,195	$ 1,007,440

[1] The condensed consolidated balance sheet at December 31, 2015 has been derived from the audited financial statements at that date.