CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenues:
Product revenues, net	$ 212,116	$ 142,406	$ 395,383	$ 257,736
Product royalty revenues	25,958	17,364	47,860	33,037
Contract revenues	8,214	3,214	66,429	31,429
Other revenues			80	58
Total revenues	246,288	162,984	509,752	322,260
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	12,367	6,254	18,372	9,229
Research and development	120,269	112,445	277,092	230,809
Selling, general and administrative	66,792	51,679	131,390	96,548
Change in fair value of acquisition-related contingent consideration	2,271		2,271
Total costs and expenses	201,699	170,378	429,125	336,586
Income (loss) from operations	44,589	(7,394)	80,627	(14,326)
Interest and other income, net	1,137	1,144	2,630	2,773
Interest expense	(9,662)	(11,494)	(19,796)	(24,181)
Unrealized gain (loss) on long term investment	(854)	27,174	(3,804)	27,174
Income (loss) before provision for income taxes	35,210	9,430	59,657	(8,560)
Provision for income taxes	785	136	1,185	503
Net income (loss)	$ 34,425	$ 9,294	$ 58,472	$ (9,063)
Net income (loss) per share:
Basic	$ 0.18	$ 0.05	$ 0.31	$ (0.05)
Diluted	$ 0.18	$ 0.05	$ 0.30	$ (0.05)
Shares used in computing net income (loss) per share:
Basic	187,682	178,676	187,433	175,373
Diluted	193,015	186,493	192,820	175,373