CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015	[1]
Current assets:
Cash and cash equivalents	$ 487,654	$ 521,439
Marketable securities-available-for-sale	141,537	186,344
Restricted cash and investments	16	516
Accounts receivable	129,486	114,450
Inventory	6,124	1,783
Prepaid expenses and other current assets	27,313	17,843
Total current assets	792,130	842,375
Restricted cash and investments	922	13,977
Long term investment	31,444	35,248
Inventory	15,540	17,555
Property and equipment, net	138,513	86,006
Other intangible assets, net	269,205
In-process research and development	12,000
Goodwill	155,725
Other assets, net	2,496	12,279
Total assets	1,417,975	1,007,440
Current liabilities:
Accounts payable	40,724	30,085
Accrued compensation	31,545	38,117
Interest payable	762	762
Accrued and other current liabilities	102,184	86,531
Deferred revenue-collaborative agreements	6,083	12,512
Acquisition-related contingent consideration	17,688
Total current liabilities	198,986	168,007
Convertible senior notes	635,491	619,893
Acquisition-related contingent consideration	276,312
Other liabilities	10,123	48,385
Total liabilities	1,120,912	836,285
Stockholders' equity:
Preferred stock, $0.001 par value; 5,000,000 shares authorized; none issued or outstanding as of June 30, 2016 and December 31, 2015
Common stock, $0.001 par value; 400,000,000 shares authorized; 187,865,985 and 186,650,249 shares issued and outstanding as of June 30, 2016 and December 31, 2015, respectively	188	187
Additional paid-in capital	2,016,728	1,950,764
Accumulated other comprehensive income (loss)	662	(809)
Accumulated deficit	(1,720,515)	(1,778,987)
Total stockholders' equity	297,063	171,155
Total liabilities and stockholders' equity	$ 1,417,975	$ 1,007,440

[1] The condensed consolidated balance sheet at December 31, 2015 has been derived from the audited financial statements at that date.