CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenues:
Product revenues, net	$ 183,267	$ 115,330
Product royalty revenues	21,903	15,673
Contract revenues	58,214	28,214
Other revenues	80	58
Total revenues	263,464	159,275
Costs and expenses:
Cost of product revenues	6,005	2,974
Research and development	156,824	118,365
Selling, general and administrative	64,596	44,871
Total costs and expenses	227,425	166,210
Income (loss) from operations	36,039	(6,935)
Interest and other income, net	1,492	1,630
Interest expense	(10,134)	(12,687)
Unrealized loss on long term investment	(2,950)
Income (loss) before provision for income taxes	24,447	(17,992)
Provision for income taxes	400	367
Net income (loss)	$ 24,047	$ (18,359)
Net income (loss) per share:
Basic	$ 0.13	$ (0.11)
Diluted	$ 0.12	$ (0.11)
Shares used in computing net income (loss) per share:
Basic	187,184	172,070
Diluted	192,625	172,070