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Summary of significant accounting policies (Details 2)
$ in Thousands
3 Months Ended
Mar. 31, 2016
USD ($)
item
category
Mar. 31, 2015
USD ($)
Revenue Recognition    
Percentage of Medicare Part D insurance coverage gap mandate to be funded by manufacturers 50.00%  
Categories of milestone events, number | category 3  
Number of stages of life-cycle drugs | item 3  
Stock-Based Compensation    
Stock-based compensation expense $ 20,800 $ 17,600
Recent Accounting Pronouncements    
Excess tax benefits (400) $ (367)
Impact of Adoption of ASU No. 2016-09    
Recent Accounting Pronouncements    
Excess tax benefit from stock based compensation 325,600  
Excess tax benefits $ 300