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Convertible Notes (Details 2)
$ / shares in Units, $ in Thousands
12 Months Ended
Nov. 15, 2013
Nov. 14, 2013
USD ($)
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
shares
Dec. 31, 2013
USD ($)
shares
Convertible Notes          
Convertible senior notes     $ 619,893 $ 589,981  
Cash used to fund redemption of notes         $ 499,994
Net proceeds from issuance of notes         728,696
Loss on debt repurchase         $ (17,934)
Carrying Amount          
Convertible Notes          
Convertible senior notes     619,893 675,167  
Long-term debt, noncurrent     619,893 589,981  
Fair Value          
Convertible Notes          
Convertible senior notes     $ 1,623,545 $ 1,893,035  
4.75% Convertible Senior Notes due 2015          
Convertible Notes          
Interest rate of debt (as a percent)     4.75% 4.75% 4.75%
Conversion ratio, number of shares per principal amount     1.1396010    
Conversion ratio, principal amount, denominator     1,000    
Conversion price per share (in dollars per share) | $ / shares     $ 8.78    
Repurchase price as a percentage of principal     100.00%    
Liability on notes on the date of issuance         $ 118,600
Equity component in convertible notes         381,400
Carrying value of notes         $ 100,700
Aggregate principal amount of notes converted     $ 90,800    
Common stock issued in exchange of notes (in shares) | shares     10,352,784 653,438 21,208,303
Aggregate principal amount of notes exchanged       $ 4,900 $ 186,000
Cash used to fund redemption of notes       300 11,500
Debt exchange expense       300 11,500
Reduction in additional paid-up capital         381,400
Repurchase of notes         117,300
Loss on debt repurchase         17,900
4.75% Convertible Senior Notes due 2015 | Carrying Amount          
Convertible Notes          
Convertible senior notes       85,186  
4.75% Convertible Senior Notes due 2015 | Fair Value          
Convertible Notes          
Convertible senior notes       $ 755,143  
4.75% Convertible Senior Notes due 2015 | Director          
Convertible Notes          
Aggregate principal amount of notes converted     $ 43,300    
Common stock issued in exchange of notes (in shares) | shares     4,900,000    
Net proceeds from issuance of notes         $ 500,000
Pfizer Notes Due 2014          
Convertible Notes          
Common stock issued in exchange of notes (in shares) | shares         1,025,641
0.375% Convertible Senior Notes due 2018 and 1.25% Convertible Senior Notes due 2020          
Convertible Notes          
Number of days within 30 consecutive trading days in which the price of the entity's common stock must exceed the conversion price for the notes to be converted   20 days      
Number of consecutive trading days during which the closing price of the entity's common stock must exceed the conversion price for at least 20 days in order for the notes to be convertible   30 days      
Percentage of the closing sales price of common stock that the conversion price must exceed in order for the notes to be convertible (as a percent)   130.00%      
Number of consecutive business days immediately after any five consecutive trading day period during the note measurement period   5 days      
Number of consecutive trading days before five consecutive business days during the note measurement period   5 days      
Percentage of the trading price to the product of the last reported sale price of the common stock and the conversion rate, maximum (as a percent)   98.00%      
Conversion ratio, principal amount, denominator 1,000        
Repurchase price as a percentage of principal     100.00%    
0.375% Convertible Senior Notes due 2018          
Convertible Notes          
Interest rate of debt (as a percent)     0.375% 0.375% 0.375%
Aggregate principal amount of notes   $ 375,000      
Conversion ratio, number of shares per principal amount     0.1932070    
Conversion ratio, principal amount, denominator     1,000    
Conversion price per share (in dollars per share) | $ / shares     $ 51.76    
Liability on notes on the date of issuance     $ 299,400    
Equity component in convertible notes     75,600    
Carrying value of notes     324,000 $ 308,000  
Debt discount and issuance costs     51,000 67,000  
0.375% Convertible Senior Notes due 2018 | Carrying Amount          
Convertible Notes          
Convertible senior notes     324,031 307,978  
0.375% Convertible Senior Notes due 2018 | Fair Value          
Convertible Notes          
Convertible senior notes     $ 807,422 $ 560,156  
0.375% Convertible Senior Notes due 2018 | Director          
Convertible Notes          
Aggregate principal amount of notes   250,000      
1.25% Convertible Senior Notes due 2020          
Convertible Notes          
Interest rate of debt (as a percent)     1.25% 1.25% 1.25%
Aggregate principal amount of notes   375,000      
Conversion ratio, number of shares per principal amount     0.1932070    
Conversion ratio, principal amount, denominator     1,000    
Conversion price per share (in dollars per share) | $ / shares     $ 51.76    
Liability on notes on the date of issuance     $ 274,800    
Equity component in convertible notes     100,200    
Carrying value of notes     295,900 $ 282,000  
Debt discount and issuance costs     $ 78,900 93,000  
Common stock issued in exchange of notes (in shares) | shares     3,902    
1.25% Convertible Senior Notes due 2020 | Carrying Amount          
Convertible Notes          
Convertible senior notes     $ 295,862 282,003  
1.25% Convertible Senior Notes due 2020 | Fair Value          
Convertible Notes          
Convertible senior notes     $ 816,123 $ 577,736  
1.25% Convertible Senior Notes due 2020 | Director          
Convertible Notes          
Aggregate principal amount of notes   $ 250,000