CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues:
Product revenues, net	$ 601,015	$ 357,562	$ 235,443
Product royalty revenues	74,821	48,966	28,251
Contract revenues	77,857	104,857	91,047
Other revenues	58	110	206
Total revenues	753,751	511,495	354,947
Costs and expenses:
Cost of product revenues	26,972	3,004	630
Research and development	479,514	347,523	260,436
Selling, general and administrative	196,614	165,772	109,983
Total costs and expenses	703,100	516,299	371,049
Income (loss) from operations	50,651	(4,804)	(16,102)
Interest and other income, net	7,089	3,350	1,324
Interest expense	(45,603)	(46,828)	(38,652)
Unrealized loss on long term investment	(4,581)
Debt exchange expense on senior note conversions		(265)	(11,484)
Loss on repurchase of convertible senior notes			(17,934)
Income (loss) before provision for income taxes	7,556	(48,547)	(82,848)
Provision (benefit) for income taxes	1,025	(66)	299
Net income (loss)	$ 6,531	$ (48,481)	$ (83,147)
Net income (loss) per share:
Basic	$ 0.04	$ (0.29)	$ (0.56)
Diluted	$ 0.03	$ (0.29)	$ (0.56)
Shares used in computing net income (loss) per share:
Basic	179,601	167,947	148,403
Diluted	187,302	167,947	148,403