CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2015	Dec. 31, 2014	[1]
Current assets:
Cash and cash equivalents	$ 445,801	$ 452,297
Marketable securities-available-for-sale	189,244	147,966
Restricted cash and investments	517	500
Accounts receivable	86,966	57,933
Inventory	2,428	358
Deferred income taxes	9,712	19,641
Prepaid expenses and other current assets	23,246	20,519
Total current assets	757,914	699,214
Restricted cash and investments	18,111	14,000
Long term investment	35,714
Inventory	17,838	19,078
Property and equipment, net	83,186	81,790
Other assets, net	19,169	15,987
Total assets	931,932	830,069
Current liabilities:
Accounts payable	27,366	24,462
Accrued compensation	30,070	34,422
Interest payable	3,316	1,841
Accrued and other current liabilities	82,209	62,270
Deferred revenue-collaborative agreements	12,857	12,880
Convertible senior notes	5	85,640
Total current liabilities	155,823	221,515
Convertible senior notes	623,928	603,478
Other liabilities	50,863	54,552
Deferred income taxes	9,712	19,641
Deferred revenue-collaborative agreements	2,869	12,511
Total liabilities	$ 843,195	$ 911,697
Stockholders' equity (deficit):
Preferred stock, $0.001 par value; 5,000,000 shares authorized; none issued or outstanding as of September 30, 2015 and December 31, 2014
Common stock, $0.001 par value; 400,000,000 shares authorized; 185,956,247 and 170,876,619 shares issued and outstanding as of September 30, 2015 and December 31, 2014, respectively	$ 186	$ 171
Additional paid-in capital	1,922,989	1,701,904
Accumulated other comprehensive (loss) income	(275)	1,815
Accumulated deficit	(1,834,163)	(1,785,518)
Total stockholders' equity (deficit)	88,737	(81,628)
Total liabilities and stockholders' equity (deficit)	$ 931,932	$ 830,069

[1] The condensed consolidated balance sheet at December 31, 2014 has been derived from the audited financial statements at that date.