X0306 4 2021-07-02 0 0000879169 INCYTE CORP INCY 0001615842 Flannelly Barry P 1801 AUGUSTINE CUT-OFF WILMINGTON DE 19803 0 1 0 0 EVP & General Manager US Common Stock 2021-07-02 4 A 0 7853 0.00 A 58143 D Common Stock 2021-07-02 4 F 0 1990 83.58 D 56153 D Common Stock 2021-07-06 4 F 0 273 83.34 D 55880 D Employee Stock Option (right to buy) 83.58 2021-07-02 4 A 0 15054 0.00 A 2031-07-01 Common Stock 15054 15054 D Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years, subject to Barry Flannelly's continued service with the issuer through the applicable vesting dates. The RSUs may be settled only for shares of common stock on a one-for-one basis. Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units or earned performance shares previously reported in Table I as common stock. Including the July 2, 2021 Restricted Stock Unit Grant, this includes an aggregate of 45,255 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance shares that have not vested. Beginning July 2, 2021, options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. /s/ Paul Trower, Attorney-In-Fact 2021-07-07