X0306 4 2016-06-26 0 0000879169 INCYTE CORP INCY 0001596492 Hoppenot Herve 1801 AUGUSTINE CUT-OFF WILMINGTON DE 19803 1 1 0 1 Chairman / CEO President Common Stock 2020-06-26 4 M 0 4647 64.55 A 245250 D Common Stock 66234 I By GRAT Common Stock 2020-06-26 4 S 0 4647 102.91 D 240603 D Common Stock 66234 I By GRAT Common Stock 2020-06-26 4 M 0 119501 64.55 A 360104 D Common Stock 66234 I By GRAT Common Stock 2020-06-26 4 S 0 119501 102.91 D 240603 D Common Stock 66234 I By GRAT Incentive Stock Option (right to buy) 64.55 2020-06-26 4 M 0 4647 0.00 D 2021-01-20 Common Stock 4647 0 D Non-Qualified Stock Option (right to buy) 65.55 2020-06-26 4 M 0 119501 0.00 D 2021-01-20 Common Stock 119501 0 D This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person. Reporting person undertakes to provide upon request by Securites and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within range indicated. Represents weighted average sale price. Actual sale prices ranged from $101.25 - $105.56. This includes an aggregate of 107,977 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance shares that have not vested. On June 15, 2018, the reporting person contributed 103,033 shares to a grantor retained annuity trust (GRAT). On June 17, 2019, 20,407 shares were distributed by the GRAT to the reporting person in accordance with the terms of the GRAT and continue to be reported in this Form 4 as directly owned. In addition, on June 2, 2020 an additional 16,392 were distributed by the GRAT to the reporting person in accordance with the terms of the GRAT and continue to be reported in this Form 4 as directly owned. Beginning January 21, 2014, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years. /s/ Herve Hoppenot 2020-06-30