X0306 4 2019-07-05 0 0000879169 INCYTE CORP INCY 0001596492 Hoppenot Herve 1801 AUGUSTINE CUT-OFF WILMINGTON DE 19803 1 1 0 1 Chairman / CEO President Common Stock 2019-07-05 4 F 0 1552 85.28 D 214596 D Common Stock 82626 I By GRAT Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units previously reported in Table I as common stock. This includes an aggregate of 139,764 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. On June 15, 2018, the reporting person contributed 103,033 shares to a grantor retained annuity trust (GRAT). On June 17, 2019, 20,407 shares were distributed by the GRAT to the reporting person in accordance with the terms of the GRAT and continue to be reported in this Form 4 as directly owned. /s/ Herve Hoppenot 2019-07-09