CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2015	Jun. 30, 2014	Jun. 30, 2015	Jun. 30, 2014
Revenues:
Product revenues, net	$ 142,406	$ 84,025	$ 257,736	$ 153,676
Product royalty revenues	17,364	12,340	33,037	22,166
Contract revenues	3,214	3,214	31,429	13,429
Other revenues		3	58	103
Total revenues	162,984	99,582	322,260	189,374
Costs and expenses:
Cost of product revenues	6,254	187	9,229	355
Research and development	112,445	84,683	230,809	160,269
Selling, general and administrative	51,679	40,899	96,548	77,873
Total costs and expenses	170,378	125,769	336,586	238,497
Loss from operations	(7,394)	(26,187)	(14,326)	(49,123)
Interest and other income, net	1,144	790	2,773	1,526
Interest expense	(11,494)	(11,406)	(24,181)	(22,849)
Unrealized gain on long term investment	27,174		27,174
Debt exchange expense on senior note conversions				(265)
Income (loss) before provision for income taxes	9,430	(36,803)	(8,560)	(70,711)
Provision for income taxes	136	70	503	119
Net income loss	$ 9,294	$ (36,873)	$ (9,063)	$ (70,830)
Net income (loss) per share:
Basic (in dollars per share)	$ 0.05	$ (0.22)	$ (0.05)	$ (0.43)
Diluted (in dollars per share)	$ 0.05	$ (0.22)	$ (0.05)	$ (0.43)
Shares used in computing net income (loss) per share:
Basic (in shares)	178,676	167,914	175,373	166,636
Diluted (in shares)	186,493	167,914	175,373	166,636