CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2015	Dec. 31, 2014	[1]
Current assets:
Cash and cash equivalents	$ 439,681	$ 452,297
Marketable securities-available-for-sale	187,788	147,966
Restricted investments	517	500
Accounts receivable	75,122	57,933
Inventory	1,897	358
Deferred income taxes	7,725	19,641
Prepaid expenses and other current assets	20,260	20,519
Total current assets	732,990	699,214
Restricted investments	14,256	14,000
Long term investment	67,003
Inventory	18,548	19,078
Property and equipment, net	81,602	81,790
Other assets, net	15,938	15,987
Total assets	930,337	830,069
Current liabilities:
Accounts payable	29,162	24,462
Accrued compensation	25,794	34,422
Interest payable	1,282	1,841
Accrued and other current liabilities	80,437	62,270
Deferred revenue-collaborative agreements	12,857	12,880
Convertible senior notes	42,940	85,640
Total current liabilities	192,472	221,515
Convertible senior notes	617,025	603,478
Other liabilities	51,858	54,552
Deferred income taxes	7,725	19,641
Deferred revenue-collaborative agreements	6,083	12,511
Total liabilities	$ 875,163	$ 911,697
Stockholders' equity (deficit):
Preferred stock, $0.001 par value; 5,000,000 shares authorized; none issued or outstanding as of June 30, 2015 and December 31, 2014
Common stock, $0.001 par value; 400,000,000 shares authorized; 180,191,498 and 170,876,619 shares issued and outstanding as of June 30, 2015 and December 31, 2014, respectively	$ 180	$ 171
Additional paid-in capital	1,847,626	1,701,904
Accumulated other comprehensive income	1,949	1,815
Accumulated deficit	(1,794,581)	(1,785,518)
Total stockholders' equity (deficit)	55,174	(81,628)
Total liabilities and stockholders' equity (deficit)	$ 930,337	$ 830,069

[1] The condensed consolidated balance sheet at December 31, 2014 has been derived from the audited financial statements at that date.