Condensed Consolidated Statements of Operations (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012	Sep. 30, 2013	Sep. 30, 2012
Revenues:
Product revenues, net	$ 60,201	$ 43,695	$ 162,589	$ 92,700
Product royalty revenues	8,184		19,893
Contract revenues	16,737	16,737	75,211	90,211
Other revenues	1	60	182	302
Total revenues	85,123	60,492	257,875	183,213
Costs and expenses:
Cost of product revenues	155	31	463	58
Research and development	71,704	50,079	185,417	150,627
Selling, general and administrative	26,447	20,520	71,956	61,634
Total costs and expenses	98,306	70,630	257,836	212,319
Income (loss) from operations	(13,183)	(10,138)	39	(29,106)
Interest and other income, net	385	27	829	393
Interest expense	(7,699)	(11,573)	(29,720)	(34,293)
Debt exchange expense	(1,491)		(11,262)
Loss before income taxes	(21,988)	(21,684)	(40,114)	(63,006)
Provision for income taxes	49	26	162	93
Net loss	$ (22,037)	$ (21,710)	$ (40,276)	$ (63,099)
Basic and diluted net loss per share: (in dollars per share)	$ (0.14)	$ (0.17)	$ (0.28)	$ (0.49)
Shares used in computing basic and diluted net loss per share (in shares)	155,067	130,851	143,899	129,093