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Stock compensation (Details) (USD $)
In Millions, except Per Share data, unless otherwise specified
3 Months Ended 9 Months Ended
Sep. 30, 2013
Sep. 30, 2012
Sep. 30, 2013
Sep. 30, 2012
Stock compensation        
Stock compensation expense $ 9.5 $ 9.5 $ 28.6 $ 29.4
Weighted-average fair value assumptions        
Valuation method     Black-Scholes valuation model  
Research and development expense
       
Stock compensation        
Stock compensation expense 6.4 6.4 19.6 19.6
Selling, general and administrative expense
       
Stock compensation        
Stock compensation expense 3.1 3.1 9.0 9.8
Employee Stock Purchase Plan
       
Weighted-average fair value assumptions        
Average risk-free interest rates (as a percent) 0.27% 0.25% 0.27% 0.25%
Average expected life 6 months 6 months 6 months 6 months
Volatility (as a percent) 51.00% 53.00% 51.00% 53.00%
Weighted-average fair value (in dollars per share) $ 3.81 $ 3.84 $ 3.81 $ 3.84
Employee Stock Options
       
Weighted-average fair value assumptions        
Average risk-free interest rates (as a percent) 1.05% 0.46% 0.59% 0.48%
Average expected life 4 years 4 months 2 days 4 years 1 month 17 days 4 years 3 months 3 years 10 months 13 days
Volatility (as a percent) 47.00% 50.00% 47.00% 57.00%
Weighted-average fair value (in dollars per share) $ 12.18 $ 8.59 $ 7.34 $ 7.84
Dividend yield (as a percent)     0.00%  
Assumed annualized forfeiture rate (as a percent)     5.00%  
Unrecognized compensation        
Unrecognized compensation cost for nonvested option (in dollars) $ 27.5   $ 27.5  
Vesting period of recognition of the unrecognized compensation cost of nonvested awards     3 years