Condensed Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Revenues:
Product revenues, net	$ 54,099	$ 29,727	$ 102,388	$ 49,006
Product royalty revenues	5,800		11,709
Contract revenues	41,737	56,737	58,474	73,474
Other revenues	39	78	181	242
Total revenues	101,675	86,542	172,752	122,722
Costs and expenses:
Cost of product revenues	157	16	308	27
Research and development	60,950	51,588	113,713	100,548
Selling, general and administrative	23,249	19,719	45,509	41,115
Total costs and expenses	84,356	71,323	159,530	141,690
Income (loss) from operations	17,319	15,219	13,222	(18,968)
Interest and other income, net	245	315	444	366
Interest expense	(10,293)	(11,430)	(22,022)	(22,720)
Debt exchange expense	(9,771)		(9,771)
Income (loss) before income taxes	(2,500)	4,104	(18,127)	(41,322)
Provision for income taxes	71	67	113	67
Net income (loss)	$ (2,571)	$ 4,037	$ (18,240)	$ (41,389)
Net income (loss) per share:
Basic (in dollars per share)	$ (0.02)	$ 0.03	$ (0.13)	$ (0.32)
Diluted (in dollars per share)	$ (0.02)	$ 0.03	$ (0.13)	$ (0.32)
Shares used in computing basic and diluted net income (loss) per share
Basic (in shares)	142,284	129,224	138,315	128,214
Diluted (in shares)	142,284	137,969	138,315	128,214