Condensed Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2013	Mar. 31, 2012
Revenues:
Product revenues, net	$ 48,289	$ 19,279
Product royalty revenues	5,909
Contract revenues	16,737	16,737
Other revenues	142	163
Total revenues	71,077	36,179
Costs and expenses:
Cost of product revenues	150	11
Research and development	52,763	48,960
Selling, general and administrative	22,261	21,396
Total costs and expenses	75,174	70,367
Loss from operations	(4,097)	(34,188)
Interest and other income, net	199	52
Interest expense	(11,728)	(11,290)
Loss before provision for income taxes	(15,626)	(45,426)
Provision for income taxes	43
Net loss	$ (15,669)	$ (45,426)
Basic and diluted net loss per share: (in dollars per share)	$ (0.12)	$ (0.36)
Shares used in computing basic and diluted net loss per share (in shares)	134,345	127,203