Condensed Consolidated Statements of Operations (USD $) In Thousands, except Per Share data	3 Months Ended		9 Months Ended
	Sep. 30, 2011	Sep. 30, 2010	Sep. 30, 2011	Sep. 30, 2010
Revenues:
Contract revenues	$ 16,737	$ 16,737	$ 65,211	$ 83,212
License and royalty revenues	45	135	354	796
Total revenues	16,782	16,872	65,565	84,008
Costs and expenses:
Research and development	44,604	30,609	126,830	91,106
Selling, general and administrative	14,282	8,458	37,067	21,563
Other expenses		(139)	712	(399)
Total costs and expenses	58,886	38,928	164,609	112,270
Loss from operations	(42,104)	(22,056)	(99,044)	(28,262)
Interest and other income, net	45	212	249	549
Interest expense	(11,019)	(10,515)	(32,666)	(32,686)
Loss on debt redemption				(3,988)
Loss before income taxes	(53,078)	(32,359)	(131,461)	(64,387)
Provision for income taxes		(658)
Net loss	$ (53,078)	$ (31,701)	$ (131,461)	$ (64,387)
Basic and diluted net loss per share: (in dollars per share)	$ (0.42)	$ (0.26)	$ (1.05)	$ (0.53)
Shares used in computing basic and diluted net loss per share
Basic (in shares)	126,260	122,189	125,019	121,182
Diluted (in shares)	126,260	122,189	125,019	121,182