CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Revenues:
Total revenues	$ 1,215,529	$ 1,043,759	$ 2,268,427	$ 1,924,648
Costs, expenses and other:
Cost of product revenues (including definite-lived intangible amortization)	78,766	76,634	151,954	137,590
Contract dispute settlement	(242,251)	0	(242,251)	0
Research and development	494,917	1,138,380	932,196	1,567,640
Selling, general and administrative	331,022	305,982	656,713	606,238
Loss on change in fair value of acquisition-related contingent consideration	22,761	893	34,333	437
(Profit) and loss sharing under collaboration agreements	0	0	0	(1,025)
Total costs, expenses and other	685,215	1,521,889	1,532,945	2,310,880
Income (loss) from operations	530,314	(478,130)	735,482	(386,232)
Interest income	25,136	41,476	48,065	88,246
Interest expense	(594)	(657)	(1,254)	(1,087)
(Loss) gain on equity investments	(4,151)	39,241	(5,494)	139,188
Other, net	7,307	8,293	15,403	6,267
Income (loss) before provision for income taxes	558,012	(389,777)	792,202	(153,618)
Provision for income taxes	153,013	54,824	229,000	121,435
Net income (loss)	$ 404,999	$ (444,601)	$ 563,202	$ (275,053)
Net income (loss) per share:
Basic (in USD per share)	$ 2.09	$ (2.04)	$ 2.91	$ (1.24)
Diluted (in USD per share)	$ 2.04	$ (2.04)	$ 2.84	$ (1.24)
Shares used in computing net income (loss) per share:
Basic (in shares)	193,995	218,175	193,853	221,329
Diluted (in shares)	198,744	218,175	198,526	221,329
Product revenues, net
Revenues:
Total revenues	$ 1,059,414	$ 906,566	$ 1,981,688	$ 1,636,489
Product royalty revenues
Revenues:
Total revenues	151,115	137,193	281,739	263,159
Milestone and contract revenues
Revenues:
Total revenues	$ 5,000	$ 0	$ 5,000	$ 25,000