Property and Equipment, net - Property and equipment, net (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Property and equipment, net
Property and Equipment, gross	$ 952,124	$ 899,640
Less accumulated depreciation and amortization	(212,814)	(175,720)
Property and equipment, net	739,310	723,920
Office equipment
Property and equipment, net
Property and Equipment, gross	22,734	22,554
Laboratory equipment
Property and equipment, net
Property and Equipment, gross	192,141	105,040
Computer equipment
Property and equipment, net
Property and Equipment, gross	92,115	79,871
Land
Property and equipment, net
Property and Equipment, gross	10,429	10,494
Building and leasehold improvements
Property and equipment, net
Property and Equipment, gross	564,170	434,321
Operating lease right-of-use assets
Property and equipment, net
Property and Equipment, gross	23,311	27,308
Construction in progress
Property and equipment, net
Property and Equipment, gross	$ 47,224	$ 220,052

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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