CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues:
Total revenues	$ 3,394,635	$ 2,986,267	$ 2,666,702
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	206,997	150,991	131,328
Research and development	1,585,936	1,458,179	2,215,942
Selling, general and administrative	1,002,140	739,560	516,922
Loss on change in fair value of acquisition-related contingent consideration	12,149	14,741	23,385
(Profit) and loss sharing under collaboration agreements	7,973	37,019	42,801
Total costs and expenses	2,815,195	2,400,490	2,930,378
Income (loss) from operations	579,440	585,777	(263,676)
Other income (expense), net	39,932	10,647	23,206
Interest expense	(2,666)	(1,908)	(2,174)
Unrealized (loss) gain on long term investments	(87,590)	(24,072)	10,426
Income (loss) before provision (benefit) for income taxes	529,116	570,444	(232,218)
Provision (benefit) for income taxes	188,456	(378,137)	63,479
Net income (loss)	$ 340,660	$ 948,581	$ (295,697)
Net income (loss) per share:
Basic (in dollars per share)	$ 1.53	$ 4.30	$ (1.36)
Diluted (in dollars per share)	$ 1.52	$ 4.27	$ (1.36)
Shares used in computing net income (loss) per share:
Weighted average common shares outstanding (in shares)	222,004	220,428	218,073
Diluted (in shares)	223,958	222,074	218,073
Product revenues, net
Revenues:
Total revenues	$ 2,746,897	$ 2,322,012	$ 2,068,736
Product royalty revenues
Revenues:
Total revenues	482,738	569,255	392,966
Milestone and contract revenues
Revenues:
Total revenues	$ 165,000	$ 95,000	$ 205,000