X0303 4 2009-01-27 0000877902 NEOSE TECHNOLOGIES INC NTEC 0001207786 DOVEY BRIAN H C/O DOMAIN ASSOCIATES, LLC ONE PALMER SQUARE PRINCETON NJ 08542 1 0 0 0 Common Stock 2009-01-27 4 M 0 2869 A 2869 D Restricted Stock Unit 2009-01-27 4 M 0 2869 0 D Common Stock 2869 0 D Each Restricted Stock Unit ("RSU") represents a contractual right to the delivery of one share of Common Stock. The RSUs were exercised and the underlying shares were issued to the Reporting Person as contractually required. The Reporting Person also indirectly beneficially owns 3,345,973 shares of Common Stock held by Domain Partners V, L.P. and 79,041 shares held by DP V Associates, L.P. The Reporting Person is a managing member of One Palmer Square Associates V, L.L.C., which is the sole general partner of Domain Partners V, L.P. and DP V Associates, L.P. Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her. Kathleen K. Schoemaker, Attorney-in-Fact 2009-02-11