X0202 4 2004-05-06 0000877902 NEOSE TECHNOLOGIES INC NTEC 0001207786 DOVEY BRIAN H C/O DOMAIN ASSOCIATES, L.L.C. ONE PALMER SQUARE PRINCETON NJ 08542 1 0 0 0 Stock Option (Right to Buy) 9.11 2004-05-06 4 A 0 10000 0 A 2004-05-06 2014-05-06 Common Stock 10000 10000 I By Domain Associates, L.L.C. The option is exercisable immediately on the date of grant, subject to the Issuer's right of repurchase. The Issuer's right of repurchase expires on May 6, 2005, the first anniversary of the date of grant. The Reporting Person is a managing member of Domain Associates, L.L.C. Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by Domain Associates, L.L.C. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his pecuniary interest therein, and/or that are not actually distributed to him. Lisa A. Kraeutler, Attorney-in-Fact 2004-05-07