Income Taxes (Narrative) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Operating Loss Carryforwards [Line Items]
Valuation allowance	$ 122,491	$ 151,791
Effective Income Tax Rate Reconciliation, Percent	(84.00%)	9.10%	(33.80%)
Unrecognized tax benefits	$ 103,542	$ 74,682	$ 84,466	$ 89,906
Accrued interest and penalties	1,600
Long-term Deferred Tax Assets
Operating Loss Carryforwards [Line Items]
Unrecognized tax benefits	89,500
Research
Operating Loss Carryforwards [Line Items]
Tax credit carryforward	228,600
Swiss Cantonal Tax Administration
Operating Loss Carryforwards [Line Items]
Deferred tax asset, attributable to impact of the Swiss TRAF	83,500		145,600
Income tax benefit due to remeasurement of Swiss deferred tax assets			112,100
Increase (decrease) to valuation allowance	(36,900)		33,500
Swiss Federal Tax Administration (FTA)
Operating Loss Carryforwards [Line Items]
Income tax benefit due to remeasurement of Swiss deferred tax assets	120,400		$ 99,900
United States
Operating Loss Carryforwards [Line Items]
Net operating loss carry forwards	370,400
Foreign jurisdictions
Operating Loss Carryforwards [Line Items]
Net operating loss carry forwards	$ 116,700