X0202 4 2007-09-04 0 0000877357 SEPRACOR INC /DE/ SEPR 0001251553 SOUTHWELL DAVID P 84 WATERFORD DRIVE MARLBOROUGH MA 01752 0 1 0 0 Chief Financial Officer Sepracor Common Stock 2007-09-04 4 S 0 420 29.43 D 73602 D Sepracor Common Stock 2007-09-04 4 S 0 683 29.44 D 72919 D Sepracor Common Stock 2007-09-04 4 S 0 300 29.45 D 72619 D Sepracor Common Stock 2007-09-04 4 S 0 400 29.46 D 72219 D Sepracor Common Stock 2007-09-04 4 S 0 500 29.47 D 71719 D Sepracor Common Stock 2007-09-04 4 S 0 400 29.48 D 71319 D Sepracor Common Stock 2007-09-04 4 S 0 3202 29.49 D 68117 D Sepracor Common Stock 2007-09-04 4 S 0 800 29.50 D 67317 D Sepracor Common Stock 2007-09-04 4 S 0 2800 29.51 D 64517 D Sepracor Common Stock 2007-09-04 4 S 0 760 29.52 D 63757 D Sepracor Common Stock 2007-09-04 4 S 0 1130 29.53 D 62627 D Sepracor Common Stock 2007-09-04 4 S 0 800 29.54 D 61827 D Sepracor Common Stock 2007-09-04 4 S 0 25 29.55 D 61802 D Sepracor Common Stock 2007-09-04 4 S 0 100 29.58 D 61702 D Sepracor Common Stock 2007-09-04 4 S 0 2300 28.54 D 59402 D Sepracor Common Stock 2007-09-04 4 S 0 2400 28.54 D 57002 D Sepracor Common Stock 2007-09-04 4 S 0 76 28.93 D 56926 D This Form 4 reports an aggregate of 17,096 shares sold by the reporting person pursuant to a Rule 10b5-1 trading plan. * This is the third of three Forms 4 filed by the reporting person on September 6, 2007 to report transactions effected on September 4, 2007. /s/ Melissa A. Schmidt, by power of attorney for David P. Southwell 2007-09-06