X0202 4 2007-09-04 0 0000877357 SEPRACOR INC /DE/ SEPR 0001251553 SOUTHWELL DAVID P 84 WATERFORD DRIVE MARLBOROUGH MA 01752 0 1 0 0 Chief Financial Officer Sepracor Common Stock 2007-09-04 4 M 0 50000 6.24 A 111702 D Sepracor Common Stock 2007-09-04 4 S 0 500 28.54 D 111202 D Sepracor Common Stock 2007-09-04 4 S 0 400 28.85 D 110802 D Sepracor Common Stock 2007-09-04 4 S 0 300 28.88 D 110502 D Sepracor Common Stock 2007-09-04 4 S 0 200 28.90 D 110302 D Sepracor Common Stock 2007-09-04 4 S 0 200 28.91 D 110102 D Sepracor Common Stock 2007-09-04 4 S 0 300 28.92 D 109802 D Sepracor Common Stock 2007-09-04 4 S 0 200 28.93 D 109602 D Sepracor Common Stock 2007-09-04 4 S 0 200 28.94 D 109402 D Sepracor Common Stock 2007-09-04 4 S 0 420 28.96 D 108982 D Sepracor Common Stock 2007-09-04 4 S 0 85 28.98 D 108897 D Sepracor Common Stock 2007-09-04 4 S 0 980 28.99 D 107917 D Sepracor Common Stock 2007-09-04 4 S 0 1300 29.00 D 106617 D Sepracor Common Stock 2007-09-04 4 S 0 500 29.01 D 106117 D Sepracor Common Stock 2007-09-04 4 S 0 300 29.02 D 105817 D Sepracor Common Stock 2007-09-04 4 S 0 815 29.03 D 105002 D Sepracor Common Stock 2007-09-04 4 S 0 900 29.04 D 104102 D Sepracor Common Stock 2007-09-04 4 S 0 930 29.05 D 103172 D Sepracor Common Stock 2007-09-04 4 S 0 1470 29.06 D 101702 D Sepracor Common Stock 2007-09-04 4 S 0 900 29.07 D 100802 D Sepracor Common Stock 2007-09-04 4 S 0 300 29.08 D 100502 D Sepracor Common Stock 2007-09-04 4 S 0 2300 29.09 D 98202 D Sepracor Common Stock 2007-09-04 4 S 0 1800 29.10 D 96402 D Sepracor Common Stock 2007-09-04 4 S 0 800 29.11 D 95602 D Sepracor Common Stock 2007-09-04 4 S 0 1399 29.13 D 94203 D Sepracor Common Stock 2007-09-04 4 S 0 1600 29.14 D 92603 D Sepracor Common Stock 2007-09-04 4 S 0 2300 29.15 D 90303 D Sepracor Common Stock Option 6.24 2007-09-04 4 M 0 50000 6.24 D 2003-08-23 2012-08-23 Sepracor Common Stock 50000 0 D This exercise was pursuant to a Rule 10b5-1 trading plan. This Form 4 reports an aggregate of 21,399 shares sold by the reporting person pursuant to a Rule 10b5-1 trading plan. See third of three Forms 4 filed on this date for the aggregate direct holdings following all transactions on September 4, 2007. * This is the first of three Forms 4 filed by the reporting person on September 6, 2007 to report transactions effected on September 4, 2007. /s/ Melissa A. Schmidt, by power of attorney for David P. Southwell 2007-09-06