SEC FORM 4

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

OSHEA WILLIAM J

(Last)

(First)

(Middle)

84 WATERFORD DRIVE

(Street)

MARLBOROUGH

01752

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
SEPRACOR INC /DE/ [ SEPR ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Vice Chairman

3. Date of Earliest Transaction (Month/Day/Year)
03/08/2007

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Sepracor Common Stock	03/08/2007		G	V	9,254⁽¹⁾	D	$0	18,397	D
Sepracor Common Stock	06/13/2007		M		100,000⁽²⁾	A	$35.74	118,397	D
Sepracor Common Stock	06/13/2007		G	V	100,000⁽¹⁾	D	$0	18,397	D
Sepracor Common Stock	06/13/2007		S⁽³⁾		35	D	$46.65	109,219	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		9	D	$46.67	109,210	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		300	D	$46.68	108,910	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		500	D	$46.69	108,410	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		200	D	$46.7	108,210	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		844	D	$46.71	107,366	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		556	D	$46.72	106,810	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		556	D	$46.73	106,164	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		827	D	$46.75	105,427	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		379	D	$46.76	105,048	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		884	D	$46.77	104,164	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		1,116	D	$46.78	103,048	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		1,000	D	$46.79	102,048	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		2,544	D	$46.8	99,504	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		2,450	D	$46.81	97,054	I	By Blund Trust
Sepracor Common Stock	06/13/2007		S		1,300	D	$46.82	95,754	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		3,700	D	$46.83	92,054	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		2,000	D	$46.84	90,054	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		1,700	D	$46.85	88,354	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		1,200	D	$46.86	87,154	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		900	D	$46.87	86,254	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		1,800	D	$46.88	84,454	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		1,100	D	$46.89	83,354	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		2,403	D	$46.9	80,951	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		2,697	D	$46.91	78,254	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		640	D	$46.92	77,614	I	By Blind Trust
Sepracor Common Stock	06/13/2007		S		1,300	D	$46.93	76,314	I	By Blind Trust

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Sepracor Common Stock Option	$35.74	06/13/2007		M		100,000		10/21/2000	10/21/2009	Sepracor Common Stock	100,000	$35.74	0	D

Explanation of Responses:

1. These shares have been gifted by the reporting person to a blind trust.

2. This exercise is pursuant to a 10b5-1 trading plan.

3. This Form 4 reports an aggregate of 32,940 shares sold by a blind trust. The reporting person contributed to the blind trust 9,254 shares on March 8, 2007 and 100,000 shares on June 13, 2007 in transactions that changed the form of beneficial ownership from direct to indirect. The trust's sales were effected pursuant to instructions given to the trustee by the reporting person on March 8, 2007, pursuant to a Rule 10b5-1 Plan. See third of three Form 4s filed on this date for the reporting person's aggregate indirect holdings following all transactions on June 13, 2007.

Remarks:

** This is the first of three Form 4's to be filed by William J. O'Shea on 6/15/07.

	/s/ Melissa A. Schmidt, by power of attorney for William J. O'Shea	06/15/2007
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.