SEC FORM 4

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

BARBERICH TIMOTHY J

(Last)

(First)

(Middle)

84 WATERFORD DRIVE

(Street)

MARLBOROUGH

01752

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
SEPRACOR INC /DE/ [ SEPR ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Executive Chairman

3. Date of Earliest Transaction (Month/Day/Year)
06/05/2007

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Sepracor Common Stock	06/05/2007		S⁽¹⁾		100	D	$48.71	210,811	I⁽²⁾	See Footnote (1) and (2)
Sepracor Common Stock	06/05/2007		S		1,100	D	$48.75	209,711	I	See Footnote (1) and (2)
Sepracor Common Stock	06/05/2007		S		700	D	$48.76	209,011	I	See Footnote (1) and (2)
Sepracor Common Stock	06/05/2007		S⁽³⁾		100	D	$48.32	208,911	I⁽⁴⁾	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		400	D	$48.36	208,511	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		800	D	$48.37	207,711	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		400	D	$48.38	207,311	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		600	D	$48.39	206,711	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		300	D	$48.4	206,411	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		600	D	$48.41	205,811	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		600	D	$48.42	205,211	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		800	D	$48.43	204,411	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		700	D	$48.44	203,711	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		300	D	$48.45	203,411	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		100	D	$48.46	203,311	I	See Footnote (3) and (4)
Seprcor Common Stock	06/05/2007		S		500	D	$48.47	202,811	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		900	D	$48.48	201,911	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		1,500	D	$48.49	200,411	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		200	D	$48.5	200,211	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		1,900	D	$48.51	198,311	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		800	D	$48.52	197,511	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		1,700	D	$48.53	195,811	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		300	D	$48.54	195,511	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		800	D	$48.55	194,711	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		1,600	D	$48.56	193,111	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		1,029	D	$48.57	192,082	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		900	D	$48.58	191,182	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		900	D	$48.59	190,282	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		1,071	D	$48.6	189,211	I	See Footnote (3) and (4)
Sepracor Common Stock	06/05/2007		S		100	D	$48.61	189,111⁽⁵⁾	I	See Footnote (3) and (4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:

1. This Form 4 reports an aggregate of 1,900 shares sold by the Sophia Barberich Trust.

2. These shares are held in trust, a trust for which the reporting person is a trustee and his minor child is the beneficiary.

3. This Form 4 reports an aggregate of 19,900 shares sold by the Lily Barberich Trust.

4. These shares are held in trust, a trust for which the reporting person is a trustee and his minor child is the beneficiary.

5. Prior to the transaction, the aggregate shares directly owned by the reporting person are 709,544 and indirectly owned by the reporting person are 189,111. Of the Aggregate, 70,247 shares are held by the Sophia Barberich Trust, Lily Barberich Trust, Christopher Barberich Trust and Joan Barberich Trust, each a trust for which the reporting person is the trustee and his minor child is the beneficiary. See seventh of seven Form 4's filed on this date for the aggregate direct and indirect holdings following all transactions on June 5, 2007.

Remarks:

** This is the fourth of seven Form 4's filed by Timothy J. Barberich on 6/7/07.

	/s/ Melissa A. Schmidt, by power of attorney for Timothy J. Barberich	06/07/2007
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.