X0202 4 2004-05-19 0 0000877357 SEPRACOR INC /DE/ SEPR 0001014093 ANDRESS JAMES G C/O XOMA LTD. 2910 SEVENTH STREET BERKELEY CA 94710 1 0 0 0 0001250676 BARRIOS DIGBY 1 0 0 0 0001198455 CRESCI ROBERT J 1 0 0 0 0001242401 MANSFORD KEITH 218 MOUNT VALE YORK X0 YO24 1DL UNITED KINGDOM 1 0 0 0 0001202064 MRAZEK JAMES F 65069 BRASSIE DRIVE TUCSON AZ 85729 1 0 0 0 0001061901 STEIGROD ALAN A 601 LIDO PARK DR STE 7A NEWPORT BEACH CA 92663 1 0 0 0 Sepracor Common Stock Option 44.15 2004-05-19 4 A 0 20000 44.15 A 2005-05-19 2014-05-18 Sepracor Common Stock 20000 163998 D Sepracor Common Stock Option 44.15 2004-05-19 4 A 0 20000 44.15 A 2005-05-19 2014-05-18 Sepracor Common Stock 20000 153333 D Sepracor Common Stock Option 44.15 2004-05-19 4 A 0 20000 44.15 A 2005-05-19 2014-05-18 Sepracor Common Stock 20000 153333 D Sepracor Common Stock Option 44.15 2004-05-19 4 A 0 20000 44.15 A 2005-05-19 2014-05-18 Sepracor Common Stock 20000 169333 D Sepracor Common Stock Option 44.15 2004-05-19 4 A 0 20000 44.15 A 2005-05-19 2014-05-18 Sepracor Common Stock 20000 129333 D Sepracor Common Stock Option 44.15 2004-05-19 4 A 0 20000 44.15 A 2005-05-19 2014-05-18 Sepracor Common Stock 20000 137333 D This transaction is reported for James Andress. This transaction is reported for Digby Barrios. This transaction is reported for Robert Cresci. This transaction is reported for Keith Mansford. This transaction is reported for James Mrazek. This transaction is reported for Alan Steigrod. Robyn McLaren, by power of attorney 2004-06-02