Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Components of Deferred Tax Assets and Liabilities

The primary components of the deferred tax assets and liabilities at December 31, 2016 and 2015 were as follows (in thousands):

Deferred tax assets/(liabilities):	2016			2015
Net operating loss carryforwards	$	78,116		$	78,268
Research and development and other credits		7,645			8,331
Patents and licenses		(67	)		(6,860	)
Equity method investments		(40,258	)		(1,333	)
Stock options		1,529			670
Other, net		2,248			(263	)
Total		49,213			78,813
Valuation allowance		(49,213	)		(78,813	)
Net deferred tax liabilities	$	-		$	-

Income Tax Rate Reconciliation

Income taxes differed from the amounts computed by applying the U.S. federal income tax of 34% to pretax losses from operations as a result of the following:

	Year Ended December 31,
	2016		2015		2014
Computed tax benefit at federal statutory rate		34%		34%		34%
Research and development and other credits		(3%)		2%		3%
Permanent differences		2%		(4%)		(1%)
Change in valuation allowance		(63%)		(34%)		(24%)
State tax benefit, net of effect on federal income taxes		24%		10%		3%
Foreign rate differential		6%		(1%)		(1%)
		-%		7%		14%