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Stock Option Plans, Allocation of Recognized Period Costs (Details) (USD $)
 12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
All stock-based compensation expense [Abstract]      
All stock-based compensation expense included in expenses $ 4,455,420us-gaap_AllocatedShareBasedCompensationExpense $ 3,044,774us-gaap_AllocatedShareBasedCompensationExpense $ 1,843,962us-gaap_AllocatedShareBasedCompensationExpense
Research and Development [Member]      
All stock-based compensation expense [Abstract]      
All stock-based compensation expense included in expenses 1,309,703us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember		 829,938us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember		 815,052us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
General and Administrative [Member]      
All stock-based compensation expense [Abstract]      
All stock-based compensation expense included in expenses $ 3,145,717us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember		 $ 2,214,836us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember		 $ 1,028,910us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember