Income Taxes - Additional Information (Details) - USD ($) $ in Thousands		1 Months Ended		12 Months Ended
	Dec. 17, 2021	Jan. 31, 2022	Dec. 31, 2021	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2021
Operating Loss Carryforwards [Line Items]
Income tax expense				$ 0	$ (1,803)
Deferred tax assets, operating loss carryforwards, domestic				177,000	163,100
Deferred tax benefit				0	1,803
Additions for tax positions related to prior years					2,609
Measurement period adjustment income tax expense benefit				1,200	1,100
Roche Agreement [Member]
Operating Loss Carryforwards [Line Items]
Upfront payment	$ 50,000	$ 50,000	$ 50,000
California [Member]
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount				$ 4,700	4,600
Tax credit carryforward limitations on use				The state of California also limited the use of their research and development credits to $5 million for tax years 2024 through 2026.
California [Member] | Research and Development [Member]
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount				$ 5,000
Net operating loss carryforwards expiration description				2024 through 2026
Cell Cure Neurosciences Ltd [Member]
Operating Loss Carryforwards [Line Items]
Gain on transaction						$ 31,700
Maximum [Member] | California [Member]
Operating Loss Carryforwards [Line Items]
Operating loss carryforward expiration year				2044
Operating loss carryforward deduction tax year				2026
Minimum [Member] | California [Member]
Operating Loss Carryforwards [Line Items]
California taxable income				$ 1,000
Operating loss carryforward expiration year				2030
Operating loss carryforward deduction tax year				2024
Pre-2018 [Member]
Operating Loss Carryforwards [Line Items]
Net operating loss carryforwards expiration description				The pre-2018 federal net operating loss carryforwards expire in varying amounts between 2030 and 2037.
Pre-2018 [Member] | Maximum [Member]
Operating Loss Carryforwards [Line Items]
Operating loss carryforward expiration year				2037
Pre-2018 [Member] | Minimum [Member]
Operating Loss Carryforwards [Line Items]
Operating loss carryforward expiration year				2030
Post-2017 [Member]
Operating Loss Carryforwards [Line Items]
Federal net operating loss carryforwards offset percent of taxable income				80.00%
Foreign Tax Jurisdiction [Member]
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards				$ 63,400	64,800
State and Local Jurisdiction [Member]
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards				213,600	188,800
Domestic Tax Jurisdiction [Member]
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount				$ 4,700	$ 4,300
Tax credit carryforward limitations on use				the credits generated each year have a carryforward period of 20 years
Net operating loss carryforwards expiration description				between 2023 and 2044