X0508 4 2023-10-13 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197036 SACHS BRUCE I C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVE BOSTON MA 02210 1 0 0 0 0 Deferred Stock Units 2023-10-13 4 A 0 118.25 369.98 A Common Stock 118.25 14643.216 D Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death. /s/ Christiana Stevenson, Attorney-in-Fact 2023-10-17